What is Glanzmann's Thrombasthenia (GT)?

Red blood cells. Computer artwork of red blood cells in a blood vessel.
Glanzmann's Thrombasthenia (GT) is an extremely rare, autosomal recessive disorder of the blood, in which the platelets lack GPIIb/IIIa. Hence, no fibrinogen bridging can occur, and bleeding time is significantly prolonged. GT can be life-threatening. Like Bernard-Soulier Syndrome, carriers experience bruising, nosebleeds, and bleeding in the mouth and gums.
Gt boy

The effects of this inherited disorder, first described in 1918, begin in early childhood. Severe intermittent bleeding from the mucous membranes occurs and, in some cases, gastrointestinal bleeding and intracranial hemorrhage follow.

gt girl

Women may experience heavy or prolonged menstrual bleeding (menorrhagia) and bleeding at the time of childbirth. Blood tests show that bleeding time is much longer than normal and platelets do not clump together at all.

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