What is Glanzmann's Thrombasthenia (GT)?
Glanzmann's Thrombasthenia (GT) is a rare inherited blood clotting (coagulation) disorder
characterized by the impaired function of specialized cells (platelets) that are essential
for proper blood clotting. Symptoms of this disorder usually include abnormal bleeding,
which may be severe. Prolonged untreated or unsuccessfully treated hemorrhaging
associated with Glanzmann's Thrombasthenia may be life threatening.
The effects of this inherited disorder, first described in 1918, begin in early childhood. Severe intermittent bleeding from the mucous membranes occurs and, in some cases, gastrointestinal bleeding and intracranial hemorrhage follow.
Women may experience heavy or prolonged menstrual bleeding (menorrhagia) and bleeding at the time of childbirth. Blood tests show that bleeding time is much longer than normal and platelets do not clump together at all.